The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2015
Filed:
Aug. 29, 2011
Vladimir L. Motin, League City, TX (US);
Sadhana Chauhan, League City, TX (US);
Scott R. Gilbertson, Galyeston, TX (US);
Anton Agarkov, Galyeston, TX (US);
Pedro Lory, Antwerp, BE;
Vladimir L. Motin, League City, TX (US);
Sadhana Chauhan, League City, TX (US);
Scott R. Gilbertson, Galyeston, TX (US);
Anton Agarkov, Galyeston, TX (US);
Pedro Lory, Antwerp, BE;
The Board of Regents of the University of Texas System, Austin, TX (US);
Abstract
The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.