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For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9187522 B1

PDFFull Text
Date of Patent:
Nov. 17, 2015

Filed:

Jun. 05, 2014

Glp-1 receptor modulators

Applicant:

Receptos, Inc., San Diego, CA (US);

Inventors:

Marcus F. Boehm, San Diego, CA (US);

Esther Martinborough, San Diego, CA (US);

Manisha Moorjani, San Diego, CA (US);

Junko Tamiya, Carlsbad, CA (US);

Liming Huang, San Diego, CA (US);

Adam R. Yeager, La Mesa, CA (US);

Enugurthi Brahmachary, San Diego, CA (US);

Thomas Fowler, Melton Mowbray, GB;

Andrew Novak, Nottingham, GB;

Premji Meghani, Leicestershire, GB;

Michael Knaggs, Burton-on-Trent, GB;

Assignee:

Receptos, Inc., San Diego, CA (US);

Attorney:

Seed IP Law Group PLLC

Primary Examiner:

Maury Audet

Assistant Examiner:

Fred Reynolds

Int. Cl.
CPC ...
A61K 31/33 (2006.01); C07K 5/072 (2006.01); C07D 233/54 (2006.01); C07D 233/60 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 239/26 (2006.01); C07D 239/34 (2006.01); C07D 409/12 (2006.01); C07D 413/04 (2006.01); C07D 241/08 (2006.01); C07D 417/12 (2006.01); C07D 255/02 (2006.01); C07D 263/32 (2006.01); C07D 271/06 (2006.01); C07D 271/107 (2006.01); C07D 495/04 (2006.01); C07D 277/24 (2006.01); C07D 285/12 (2006.01); C07D 211/22 (2006.01); A61K 31/4245 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/551 (2006.01); A61K 38/26 (2006.01); C07D 243/08 (2006.01); C07D 403/12 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); A61K 45/06 (2006.01); C07D 291/00 (2006.01); A61K 31/426 (2006.01); A61K 31/433 (2006.01); A61K 31/4439 (2006.01); A61K 38/05 (2006.01); C07D 277/30 (2006.01); C07D 285/08 (2006.01);
U.S. Cl.
CPC ...
C07K 5/06113 (2013.01); A61K 31/33 (2013.01); A61K 31/426 (2013.01); A61K 31/4245 (2013.01); A61K 31/433 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/4709 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/551 (2013.01); A61K 38/05 (2013.01); A61K 38/26 (2013.01); A61K 45/06 (2013.01); C07D 211/22 (2013.01); C07D 233/54 (2013.01); C07D 233/60 (2013.01); C07D 239/26 (2013.01); C07D 239/34 (2013.01); C07D 241/08 (2013.01); C07D 243/08 (2013.01); C07D 255/02 (2013.01); C07D 263/32 (2013.01); C07D 271/06 (2013.01); C07D 271/107 (2013.01); C07D 277/24 (2013.01); C07D 277/30 (2013.01); C07D 285/08 (2013.01); C07D 285/12 (2013.01); C07D 291/00 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 409/12 (2013.01); C07D 413/04 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 495/04 (2013.01);
Abstract

The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds are act as modulators or potentiators of GLP-1 receptor on their own, or with receptor ligands including GLP-1 peptides GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where '' represents either or both the R and S form of the compound): where A, B, C, Y, Y, Z, R, R, R, R, R, W, n, p and q are as defined herein.

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