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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9187497 B1

PDFFull Text
Date of Patent:
Nov. 17, 2015

Filed:

Aug. 01, 2014

Substituted pyrido[3,2-e]pyrrolo[1,2-a]pyrazines as inhibitors of poly(adp-ribose)polymerase (parp)

Applicants:

Anthony R. Gangloff, San Diego, CA (US);

Andrew John Jennings, San Diego, CA (US);

Benjamin Jones, San Diego, CA (US);

Andre A. Kiryanov, San Diego, CA (US);

Inventors:

Anthony R. Gangloff, San Diego, CA (US);

Andrew John Jennings, San Diego, CA (US);

Benjamin Jones, San Diego, CA (US);

Andre A. Kiryanov, San Diego, CA (US);

Assignee:

Takeda Phamaceutical Company Limited, Osaka, JP;

Attorneys:

Matthew J. Russo

Mitchell R. Brustein

Primary Examiner:

Douglas M Willis

Int. Cl.
CPC ...
C07D 471/14 (2006.01); C07D 513/14 (2006.01); C07D 471/04 (2006.01); C07D 498/14 (2006.01); A61K 31/4985 (2006.01); A61K 31/506 (2006.01); A61K 31/53 (2006.01); A61K 31/5383 (2006.01); A61K 31/542 (2006.01); A61K 45/06 (2006.01); A61K 31/5517 (2006.01); A61K 31/635 (2006.01);
U.S. Cl.
CPC ...
C07D 513/14 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/53 (2013.01); A61K 31/5383 (2013.01); A61K 31/542 (2013.01); A61K 31/5517 (2013.01); A61K 31/635 (2013.01); A61K 45/06 (2013.01); C07D 471/04 (2013.01); C07D 471/14 (2013.01); C07D 498/14 (2013.01);
Abstract

Disclosed are compounds of the following formula: in which R, R, R, R, R, R, u, and X are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.

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