The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2015
Filed:
Apr. 19, 2012
Derin C. D'amico, Newbury Park, CA (US);
Bradley J. Herberich, Newbury Park, CA (US);
Claire L. M. Jackson, Thousand Oaks, CA (US);
Liping H. Pettus, Thousand Oaks, CA (US);
Andrew Tasker, Simi Valley, CA (US);
Hui-ling Wang, Thousand Oaks, CA (US);
Bin Wu, Thousand Oaks, CA (US);
Ryan Wurz, Newbury Park, CA (US);
Derin C. D'amico, Newbury Park, CA (US);
Bradley J. Herberich, Newbury Park, CA (US);
Claire L. M. Jackson, Thousand Oaks, CA (US);
Liping H. Pettus, Thousand Oaks, CA (US);
Andrew Tasker, Simi Valley, CA (US);
Hui-Ling Wang, Thousand Oaks, CA (US);
Bin Wu, Thousand Oaks, CA (US);
Ryan Wurz, Newbury Park, CA (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
The invention relates to bicyclic compounds of formulas I and I', and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.