The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 17, 2015

Filed:

May. 02, 2013
Applicants:

Southern Research Institute, Birmingham, AL (US);

The Uab Research Foundation, Birmingham, AL (US);

Inventors:

Robert A. Galemmo, Jr., San Francisco, CA (US);

Andrew B. West, Birmingham, AL (US);

Joseph A. Maddry, Birmingham, AL (US);

Subramaniam Ananthan, Birmingham, AL (US);

Ashish Kumar Pathak, Birmingham, AL (US);

Jacob Valiyaveettil, Hoover, AL (US);

Assignees:

Southern Research Institute, Birmingham, AL (US);

The UAB Research Foundation, Birmingham, AL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/50 (2006.01); A61K 31/501 (2006.01); C07D 487/00 (2006.01); C07D 487/04 (2006.01); A61K 31/5025 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/5025 (2013.01);
Abstract

Provided are novel LRRK2 kinase inhibitors and methods of treating disease states using these inhibitors. Examples of LRRK2 kinase inhibitors are compounds of the formula: or derivatives thereof. An example is 1-(piperidin-1-yl)-2-((3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butan-1-one. Particular uses include treating neurodegenerative diseases, cancer, autoimmune diseases and leprosy.


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