The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 17, 2015

Filed:

Aug. 06, 2012
Applicants:

Cyrus K. Becker, Sunnyvale, CA (US);

George F. Schreiner, Sunnyvale, CA (US);

Sundeep Dugar, Sunnyvale, CA (US);

Dinesh Mahajan, Sunnyvale, CA (US);

Inventors:

Cyrus K. Becker, Sunnyvale, CA (US);

George F. Schreiner, Sunnyvale, CA (US);

Sundeep Dugar, Sunnyvale, CA (US);

Dinesh Mahajan, Sunnyvale, CA (US);

Assignee:

CARDERO THERAPEUTICS, INC., Sunnyvale, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 311/62 (2006.01); C07D 405/10 (2006.01); A61K 31/353 (2006.01); A61K 31/496 (2006.01);
U.S. Cl.
CPC ...
C07D 311/62 (2013.01); A61K 31/353 (2013.01); A61K 31/496 (2013.01); C07D 405/10 (2013.01);
Abstract

The present invention relates to compounds, compositions, and methods for treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more epicatechin derivatives in an amount effective to stimulate mitochondrial function in cells. The compounds, compositions, and methods described herein provide for reducing infarct size in the heart following permanent ischemia or ischemia/reperfusion event or method for delaying, attenuating or preventing adverse cardiac remodeling, and can assist in prevention of impaired mitochondria biogenesis and thus prevention of the consequences of impaired mitochondrial biogenesis in various diseases and conditions, as well as provide for the active therapy of mitochondrial depletion that may have already occurred.


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