The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 17, 2015

Filed:

Oct. 27, 2011
Applicants:

Oscar M. Moradei, Burlington, MA (US);

Sheldon Crane, Ile-Perrot, CA;

Daniel J. Mckay, Ottawa, CA;

Marie-eve Lebrun, Dollard-des-Ormeaux, CA;

Vouy Linh Truong, Pierrefonds, CA;

Inventors:

Oscar M. Moradei, Burlington, MA (US);

Sheldon Crane, Ile-Perrot, CA;

Daniel J. McKay, Ottawa, CA;

Marie-Eve Lebrun, Dollard-des-Ormeaux, CA;

Vouy Linh Truong, Pierrefonds, CA;

Assignee:

Merck Canada Inc., Kirkland, Province of Quebec, CA;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 311/41 (2006.01); C07C 311/42 (2006.01); C07D 231/12 (2006.01); C07D 261/08 (2006.01); C07D 277/64 (2006.01); C07D 239/26 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); A61K 31/428 (2006.01); A61K 31/42 (2006.01); A61K 31/415 (2006.01); A61K 31/4439 (2006.01); A61K 31/4412 (2006.01); A61K 31/506 (2006.01); A61K 31/18 (2006.01); C07C 311/18 (2006.01); C07C 311/29 (2006.01); C07C 317/40 (2006.01); C07C 323/49 (2006.01); C07D 213/75 (2006.01); A61K 31/63 (2006.01); A61K 31/635 (2006.01); A61K 45/06 (2006.01); C07D 277/62 (2006.01);
U.S. Cl.
CPC ...
C07C 311/18 (2013.01); A61K 31/428 (2013.01); A61K 31/4439 (2013.01); A61K 31/506 (2013.01); A61K 31/63 (2013.01); A61K 31/635 (2013.01); A61K 45/06 (2013.01); C07C 311/29 (2013.01); C07C 311/41 (2013.01); C07C 317/40 (2013.01); C07C 323/49 (2013.01); C07D 213/75 (2013.01); C07D 231/12 (2013.01); C07D 239/26 (2013.01); C07D 261/08 (2013.01); C07D 277/62 (2013.01); C07D 277/64 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07C 2101/02 (2013.01);
Abstract

Compounds of Formula I are disclosed: wherein L, A, R, R, R, R, R, R, R, Rand Rare defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.


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