The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 17, 2015

Filed:

Oct. 18, 2012
Applicant:

Molecular Devices, Llc, Sunnyvale, CA (US);

Inventor:

Edward D. Verdonk, San Jose, CA (US);

Assignee:

Molecular Devices, LLC, Sunnyvale, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/487 (2006.01); C40B 60/10 (2006.01); B01L 3/00 (2006.01); C40B 60/12 (2006.01); B01L 3/02 (2006.01);
U.S. Cl.
CPC ...
B01L 3/5085 (2013.01); C40B 60/12 (2013.01); G01N 33/48728 (2013.01); B01J 2219/0074 (2013.01); B01J 2219/00317 (2013.01); B01J 2219/00369 (2013.01); B01J 2219/00653 (2013.01); B01L 3/0275 (2013.01); B01L 2300/0609 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0829 (2013.01);
Abstract

Multi-well plates having contoured well designs allow multi-stage high throughput parallel assaying of ion channels or ion transporters. A well of a multi-well plate has a bottom region that is sized and shaped to simultaneously accommodate a sensing electrode and a pipette for delivering test compounds, wash fluid, and optionally ligands. The multi-well plates when coupled with an instrument having a pipette head and an electrode plate facilitates fluidic contact between cells and fluids delivered via a pipette for washing of wells with buffers or other wash solutions for serial exposure of test cells to various reagents or other stimuli. The control and test experiments are performed on the same cell (or cells) in a single well.


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