The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2015
Filed:
Dec. 09, 2013
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Amin I. Kassis, Chestnut Hill, MA (US);
Ravi S. Harapanhalli, Silver Spring, MD (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61K 51/04 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0491 (2013.01); A61K 47/48338 (2013.01); A61K 51/0459 (2013.01); A61K 51/0472 (2013.01); A61K 51/0489 (2013.01);
Abstract
The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is produced within a specific site (e.g., tumor) at concentrations that are higher than that in normal tissues. Alternatively, the enzyme is conjugated to a targeting moiety such as an antibody or a receptor-binding molecule.