The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2015
Filed:
Mar. 01, 2011
Helen Burt, Vancouver, CA;
Donald Brooks, Vancouver, CA;
Jayachandran Kizhakkedathu, New Westminster, CA;
Richard Liggins, Coquitlam, CA;
Dechi Guan, Vancouver, CA;
LU YE, Richmond, CA;
Clement Mugabe, Vancouver, CA;
Alan SO, Vancouver, CA;
Martin E. Gleave, Vancouver, CA;
John K. Jackson, Vancouver, CA;
Rajesh Kumar Kainthan, Tappan, NY (US);
Helen Burt, Vancouver, CA;
Donald Brooks, Vancouver, CA;
Jayachandran Kizhakkedathu, New Westminster, CA;
Richard Liggins, Coquitlam, CA;
Dechi Guan, Vancouver, CA;
Lu Ye, Richmond, CA;
Clement Mugabe, Vancouver, CA;
Alan So, Vancouver, CA;
Martin E. Gleave, Vancouver, CA;
John K. Jackson, Vancouver, CA;
Rajesh Kumar Kainthan, Tappan, NY (US);
The University of British Columbia, Vancouver, CA;
Centre for Drug Research and Development, Vancouver, CA;
Abstract
Herein are provided derivatized hyperbranched polyglycerols ('dHPGs'). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with CCalkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co-treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs.