The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2015
Filed:
May. 31, 2012
Applicants:
Takaji Wakita, Tokyo, JP;
Asako Murayama, Tokyo, JP;
Takanobu Kato, Yokohama, JP;
Inventors:
Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/76 (2015.01); C12N 7/00 (2006.01); C07K 14/005 (2006.01); A61K 39/12 (2006.01);
U.S. Cl.
CPC ...
A61K 35/76 (2013.01); A61K 39/12 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 2770/24222 (2013.01); C12N 2770/24234 (2013.01); G01N 2333/186 (2013.01); G01N 2500/00 (2013.01);
Abstract
A nucleic acid includes the 5' untranslated region, a virus protein-coding region including the NS3 protein coding sequence, the NS4A protein coding sequence, the NS4B protein coding sequence, the NS5A protein coding sequence, and the NS5B protein coding sequence, and the 3′ untranslated region of the HCV J6CF genome in that order from the 5′ to 3′ direction. The NS4A protein coding sequence has a mutation for substituting alanine at position 1680 with glutamic acid, as determined on the basis of the amino acid sequence of the precursor protein of the J6CF strain.