The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2015
Filed:
Apr. 15, 2008
Ian Christopher Parsons, Belmont, MA (US);
Jonathan Lansing, Reading, MA (US);
Carlos J. Bosques, Arlington, MA (US);
Daniela Beccati, Boston, MA (US);
Ian Christopher Parsons, Belmont, MA (US);
Jonathan Lansing, Reading, MA (US);
Carlos J. Bosques, Arlington, MA (US);
Daniela Beccati, Boston, MA (US);
Momenta Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The present disclosure provides a method for determining the relative conformations of a protein provided in different protein preparations, comprising steps of: (i) obtaining a first 2D NOESY NMR spectrum of a first protein preparation; (ii) obtaining a second 2D NOESY NMR spectrum of a second protein preparation; and (iii); determining whether a protein has a different conformation in the first and second protein preparations by comparing one or more cross-peaks in the first 2D NOESY NMR spectrum with one or more corresponding cross-peaks in the second 2D NOESY NMR spectrum.