The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2015
Filed:
Jan. 16, 2014
Applicant:
Fred Hutchinson Cancer Research Center, Seattle, WA (US);
Inventors:
Valeri I. Vasioukhin, Seattle, WA (US);
John R. Chevillet, Seattle, WA (US);
Assignee:
Fred Hutchinson Cancer Research Center, Seattle, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/99 (2006.01); A61K 31/34 (2006.01); G01N 33/574 (2006.01); A61K 31/40 (2006.01); A61K 31/433 (2006.01); A61K 31/473 (2006.01); A61K 31/506 (2006.01); A61K 31/536 (2006.01); A61K 31/343 (2006.01); A61K 49/00 (2006.01); A61K 51/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/574 (2013.01); A61K 31/343 (2013.01); A61K 31/40 (2013.01); A61K 31/433 (2013.01); A61K 31/473 (2013.01); A61K 31/506 (2013.01); A61K 31/536 (2013.01); A61K 49/0004 (2013.01); A61K 49/0017 (2013.01); A61K 51/00 (2013.01); C12N 9/99 (2013.01);
Abstract
Compositions and methods are provided for preventing or attenuating cancer progression or blocking metastasis in prostate cancer and other cancers (e.g., ovarian carcinoma, endometrial cancer, renal cell carcinoma) that are characterized by overexpression of the type II cell surface serine protease hepsin, based on the discovery of multiple disclosed compounds having activity as specific hepsin inhibitors.