The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2015
Filed:
Jun. 11, 2012
Wendy J. Fantl, San Francisco, CA (US);
Santosh K. Putta, Foster City, CA (US);
Omar D. Perez, San Francisco, CA (US);
Helen L. Francis-lang, San Francisco, CA (US);
Aileen C. Cohen, Palo Alto, CA (US);
Wendy J. Fantl, San Francisco, CA (US);
Santosh K. Putta, Foster City, CA (US);
Omar D. Perez, San Francisco, CA (US);
Helen L. Francis-Lang, San Francisco, CA (US);
Aileen C. Cohen, Palo Alto, CA (US);
NODALITY, INC., South San Francisco, CA (US);
Abstract
This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of cells present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens. The physiological status of a cell can be determined by comparing the intracellular status of one or more activation elements (e.g. the phosphorylation status of a signaling molecule) in a cell (e.g. a cancer cell) to that of another cell (e.g. a normal cell). The physiological status of a cell can be further classified by adding one or more modulators (e.g. an inhibitor or activator) to the cell in question. In some embodiments, the invention is directed to methods of determining a phenotypic profile of a population of cells.