The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2015
Filed:
Oct. 24, 2014
Applicant:
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Inventors:
Richard A. Young, Boston, MA (US);
Warren Whyte, Chelsea, MA (US);
Denes Hnisz, Cambridge, MA (US);
Jakob Loven, Belmont, MA (US);
Heather Hoke, Cambridge, MA (US);
David Orlando, Somerville, MA (US);
Charles Y. Lin, Boston, MA (US);
Tony Lee, Somerville, MA (US);
Assignee:
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A01N 25/00 (2006.01); A61K 47/00 (2006.01); C12Q 1/68 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6804 (2013.01); C12N 15/85 (2013.01); C12Q 1/6869 (2013.01); C12Q 1/6897 (2013.01); C12N 2830/00 (2013.01);
Abstract
The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer).