The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2015
Filed:
Apr. 20, 2010
Applicants:
Christian Rohlff, Oxon, GB;
Jonathan Alexander Terrett, San Jose, CA (US);
Inventors:
Christian Rohlff, Oxon, GB;
Jonathan Alexander Terrett, San Jose, CA (US);
Assignee:
Oxford Bio Therapeutics Ltd., Abingdon, GB;
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 16/30 (2006.01); A61K 39/00 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61K 39/00 (2013.01); A61K 47/48569 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/77 (2013.01); C07K 2317/80 (2013.01);
Abstract
The present disclosure provides antibodies, including isolated monoclonal antibodies, which specifically bind to Cadherin-17 with high affinity. Nucleic acid molecules encoding Cadherin-17 antibodies, expression vectors, host cells and methods for expressing the Cadherin-17 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the Cadherin-17 antibodies are also provided. Methods for detecting Cadherin-17, as well as methods for treating various cancers, including colorectal cancer, are disclosed.