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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9181277 B1

PDFFull Text
Date of Patent:
Nov. 10, 2015

Filed:

Nov. 14, 2012

Aminoquinazoline derivatives and their salts and methods of use

Applicant:

Sunshine Lake Pharma Co., Ltd., Dongguan, Guangdong, CN;

Inventors:

Jiancun Zhang, San Mateo, CA (US);

Yingjun Zhang, Dongguan, CN;

Weihong Zhang, Dongguan, CN;

Bing Liu, Dongguan, CN;

Jiquan Zhang, Dongguan, CN;

Jinlei Liu, Dongguan, CN;

Lu Zhang, Dongguan, CN;

Assignee:

SUNSHINE LAKE PHARMA CO., LTD., Dongguan, Guangdong, CN;

Attorneys:

Kam. W. Law

Squire Patton Boggs

Primary Examiner:

Emily Bernhardt

Int. Cl.
CPC ...
A61K 31/517 (2006.01); A61K 31/5383 (2006.01); C07D 403/12 (2006.01); C07D 487/04 (2006.01); C07D 491/052 (2006.01); C07D 491/056 (2006.01); C07D 491/048 (2006.01); C07D 513/04 (2006.01); C07D 498/04 (2006.01); C07D 401/12 (2006.01); C07D 471/04 (2006.01); C07D 495/04 (2006.01); A61K 45/06 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/5383 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 491/048 (2013.01); C07D 491/052 (2013.01); C07D 491/056 (2013.01); C07D 495/04 (2013.01); C07D 498/04 (2013.01);
Abstract

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

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