The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2015
Filed:
May. 16, 2013
Janssen Pharmaceuticals, Inc., Titusville, NJ (US);
Cellzome Limited, Brentford, Middlesex, GB;
Frederik Jan Rita Rombouts, Antwerpen, BE;
Andrés Avelino Trabanco-Suarez, Toldeo, ES;
Henricus Jacobus Maria Gijsen, Breda, BE;
Gregor James MacDonald, Zoersel, BE;
François Paul Bischoff, Vosselaar, BE;
Sergio-Alvar Alonso-de-Diego, Toledo, ES;
Adriana Ingrid Velter, Antwerpen, BE;
Yves Emiel Maria Van Roosbroeck, Antwerpen, BE;
Janssen Pharmaceuticals, Inc., Titusville, NJ (US);
Cellzome Limited, Cambridgeshire, GB;
Abstract
The present invention is concerned with novel substituted 3,4-dihydro-2H-pyrido[1,2- a]pyrazine-1,6-dione derivatives of Formula (I) wherein R, R, R, R, R, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.