The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 10, 2015

Filed:

Feb. 04, 2011
Applicants:

Shifeng Pan, San Diego, CA (US);

John E. Tellew, La Jolla, CA (US);

Yongqin Wan, Irvine, CA (US);

Yongping Xie, San Diego, CA (US);

Xing Wang, San Diego, CA (US);

Xia Wang, San Diego, CA (US);

Shenlin Huang, San Diego, CA (US);

Zuosheng Liu, San Diego, CA (US);

Qiong Zhang, El Cerrito, CA (US);

Inventors:

Shifeng Pan, San Diego, CA (US);

John E. Tellew, La Jolla, CA (US);

Yongqin Wan, Irvine, CA (US);

Yongping Xie, San Diego, CA (US);

Xing Wang, San Diego, CA (US);

Xia Wang, San Diego, CA (US);

Shenlin Huang, San Diego, CA (US);

Zuosheng Liu, San Diego, CA (US);

Qiong Zhang, El Cerrito, CA (US);

Assignee:

NOVARTIS AG, Basel, CH;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/444 (2006.01); C07D 213/75 (2006.01); C07D 471/04 (2006.01); C07D 401/14 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/444 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01);
Abstract

The invention provides a novel class of compounds of Formula (I) (wherein A, Y, R, R, Rand Rare defined in the summary of the invention), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.


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