The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2015
Filed:
Aug. 24, 2012
Koji Matsuyama, Osaka, JP;
Masanori Hatsuda, Osaka, JP;
Masahiko Yoshinaga, Osaka, JP;
Mitsuhiro Yada, SanyoOnoda, JP;
Koichi Tanimoto, Osaka, JP;
Koji Matsuyama, Osaka, JP;
Masanori Hatsuda, Osaka, JP;
Masahiko Yoshinaga, Osaka, JP;
Mitsuhiro Yada, SanyoOnoda, JP;
Koichi Tanimoto, Osaka, JP;
MITSUBISHI TANABE PHARMA CORPORATION, Osaka-Shi, JP;
Abstract
The present invention provides an industrially advantageous method for producing an optically active naphthalene compound useful as a therapeutic agent for dermatitis or the like. Specifically, the present invention provides a method for producing an optically active naphthalene compound [I], which comprises: a step of reacting a compound [a-1] and a compound [b-1] with each other in the presence of a base and a catalyst that is composed of a Pd compound and a tertiary phosphine ligand (step a); a step of asymmetrically hydrogenating a compound [c-1] in the presence of a hydrogen donor and a complex that is prepared from a ruthenium compound and a chiral ligand, or alternatively in the presence of an optically active oxazaborolidine compound (a CBS catalyst) and a boron hydride compound (step b); and a step of treating a compound [d-1] with a reducing agent (step c). (In the above formulae, Rand Rrepresent the same or different lower alkyl groups; and Xrepresents a halogen atom.).