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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9181198 B1

PDFFull Text
Date of Patent:
Nov. 10, 2015

Filed:

Jul. 27, 2011

Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use

Applicants:

Alberto Ortega Muñoz, Barcelona, ES;

Matthew Colin Thor Fyfe, Chipping Norton, GB;

Marc Martinell Pedemonte, Barcelona, ES;

Iñigo Tirapu Fernandez DE LA Cuesta, Barcelona, ES;

Maria DE Los Ángeles Estiarte-martínez, Barcelona, ES;

Inventors:

Alberto Ortega Muñoz, Barcelona, ES;

Matthew Colin Thor Fyfe, Chipping Norton, GB;

Marc Martinell Pedemonte, Barcelona, ES;

Iñigo Tirapu Fernandez de la Cuesta, Barcelona, ES;

Maria de los Ángeles Estiarte-Martínez, Barcelona, ES;

Assignee:

Oryzon Genomics S.A., Cornella de Llobregat, Barcelona, ES;

Attorney:

Finnegan, Henderson, Farabow, Garrett & Dunner

Primary Examiner:

Shengjun Wang

Int. Cl.
CPC ...
C07D 285/12 (2006.01); C07D 271/12 (2006.01); C07D 263/02 (2006.01); C07D 275/02 (2006.01); C07D 261/02 (2006.01); C07D 239/42 (2006.01); A61K 31/433 (2006.01); A61K 31/4245 (2006.01); A61K 31/422 (2006.01); C07D 213/73 (2006.01); C07D 237/20 (2006.01); C07D 241/20 (2006.01); C07D 253/07 (2006.01); C07D 261/14 (2006.01); C07D 263/48 (2006.01); C07D 271/07 (2006.01); C07D 271/113 (2006.01); C07D 277/40 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 285/135 (2006.01);
U.S. Cl.
CPC ...
C07D 239/42 (2013.01); A61K 31/422 (2013.01); A61K 31/4245 (2013.01); A61K 31/433 (2013.01); C07D 213/73 (2013.01); C07D 237/20 (2013.01); C07D 241/20 (2013.01); C07D 253/07 (2013.01); C07D 261/14 (2013.01); C07D 263/48 (2013.01); C07D 271/07 (2013.01); C07D 271/113 (2013.01); C07D 277/40 (2013.01); C07D 285/12 (2013.01); C07D 285/135 (2013.01); C07D 401/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01);
Abstract

The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection. Thus, in one specific aspect the invention relates to formulas (II), (III), (IV), (V), (VI), (VII), (VIII), (IX).

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