The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 10, 2015

Filed:

May. 17, 2011
Applicants:

Yunlong Song, Shanghai, CN;

Xiaodan Fu, Shanghai, CN;

Yunpeng Qi, Shanghai, CN;

Yves G. Pommier, Bethesda, MD (US);

Inventors:

Yunlong Song, Shanghai, CN;

Xiaodan Fu, Shanghai, CN;

Yunpeng Qi, Shanghai, CN;

Yves G. Pommier, Bethesda, MD (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); C07D 221/18 (2006.01); C07D 221/22 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01); C07D 401/06 (2006.01); A61K 9/48 (2006.01);
U.S. Cl.
CPC ...
C07D 221/18 (2013.01); A61K 9/4858 (2013.01); A61K 9/4866 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 413/12 (2013.01);
Abstract

An indenoquinolone compounds of Formula (A) is disclosed, wherein the definition of each group is described in the description. These compounds may specifically inhibit topoisomerase I, and they have good activities against many kinds of human tumor cells, such as lung cancer, colon cancer, breast cancer, liver cancer and the like. They can be used in the manufacture of antitumor drugs. The method for preparing the compound of formula (A), and pharmaceutical compositions containing such compounds and the use in the manufacture of antitumor drugs are also disclosed.


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