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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9180192 B1

PDFFull Text
Date of Patent:
Nov. 10, 2015

Filed:

Oct. 22, 2010

Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Applicants:

P. Jeffrey Conn, Brentwood, TN (US);

Craig W. Lindsley, Brentwood, TN (US);

Corey R. Hopkins, Nolensville, TN (US);

Colleen M. Niswender, Brentwood, TN (US);

Rocco D. Gogliotti, Kingston Springs, TN (US);

Inventors:

P. Jeffrey Conn, Brentwood, TN (US);

Craig W. Lindsley, Brentwood, TN (US);

Corey R. Hopkins, Nolensville, TN (US);

Colleen M. Niswender, Brentwood, TN (US);

Rocco D. Gogliotti, Kingston Springs, TN (US);

Assignee:

Vanderbilt University, Nashville, TN (US);

Attorneys:

Stites & Harbison PLLC

Richard S. Myers, Jr.

Primary Examiner:

Barbara P Badio

Assistant Examiner:

Sara E Townsley

Int. Cl.
CPC ...
A61K 31/4155 (2006.01); C07D 231/10 (2006.01); C07D 231/38 (2006.01); C07D 403/12 (2006.01); A61K 45/06 (2006.01); A61K 31/415 (2006.01); A61K 31/4439 (2006.01); C07D 231/40 (2006.01); C07D 401/12 (2006.01); C07D 417/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); A61K 31/40 (2006.01); A61K 31/4025 (2006.01); A61K 31/427 (2006.01); A61K 31/4709 (2006.01); A61K 31/506 (2006.01); A61K 31/538 (2006.01); C07D 207/48 (2006.01); C07D 405/12 (2006.01); C07D 413/14 (2006.01);
U.S. Cl.
CPC ...
A61K 45/06 (2013.01); A61K 31/40 (2013.01); A61K 31/4025 (2013.01); A61K 31/415 (2013.01); A61K 31/427 (2013.01); A61K 31/4439 (2013.01); A61K 31/4709 (2013.01); A61K 31/506 (2013.01); A61K 31/538 (2013.01); C07D 207/48 (2013.01); C07D 231/40 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01);
Abstract

Pyrazole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

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