The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2015
Filed:
Aug. 20, 2012
Applicants:
Johan Auwerx, Buchillon, CH;
Richardus Houtkooper, Amsterdam, NL;
Laurent Mouchiroud, Morges, CH;
Inventors:
Assignee:
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPEL), Lausanne, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 31/65 (2006.01); A61K 31/713 (2006.01); C12N 15/113 (2010.01); G01N 33/50 (2006.01); A61K 31/165 (2006.01); A61K 49/00 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
A61K 31/65 (2013.01); A61K 31/165 (2013.01); A61K 31/713 (2013.01); A61K 49/0008 (2013.01); C12N 15/113 (2013.01); C12Q 1/6897 (2013.01); G01N 33/5023 (2013.01); G01N 33/5079 (2013.01); G01N 33/5085 (2013.01); C12N 2310/14 (2013.01);
Abstract
The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrial disease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including inhibiting the mitochondrial translation machinery function, as well as methods for screening agents that are able to increase lifespan, inhibit or delay aging, and/or prevent or treat an age-related disease or disorder, or a mitochondrial disease or disorder, in a subject.