The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2015
Filed:
Aug. 01, 2011
Heinz Hillen, Hassloch, DE;
Andreas Striebinger, Speyer, DE;
Carsten Krantz, Allschwll, DE;
Achim Moeller, Grunstadt, DE;
Reinhold Mueller, Schifferstadt, DE;
Heinz Hillen, Hassloch, DE;
Andreas Striebinger, Speyer, DE;
Carsten Krantz, Allschwll, DE;
Achim Moeller, Grunstadt, DE;
Reinhold Mueller, Schifferstadt, DE;
AbbVie Deutschland GmbH & Co. KG, Wiesbaden, DE;
Abstract
The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-β(1-42) proteins, the production and use thereof.