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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9176122 B1

PDFFull Text
Expired
Date of Patent:
Nov. 03, 2015

Filed:

Mar. 24, 2009

Biomarkers for predicting response to immunosuppressive therapy

Applicant:

Pearlie K. Burnette, Tampa, FL (US);

Inventor:

Pearlie K. Burnette, Tampa, FL (US);

Assignees:

UNIVERSITY OF SOUTH FLORIDA, Tampa, FL (US);

UNITED STATES DEPARTMENT OF VETERANS AFFAIRS, Washington, DC (US);

Attorney:

Saliwanchik, Lloyd & Eisenschenk

Primary Examiner:

Michail Belyavskyi

Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/38 (2006.01); A61K 38/00 (2006.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5094 (2013.01); G01N 33/57426 (2013.01); G01N 33/6875 (2013.01); G01N 2333/70564 (2013.01); G01N 2333/70589 (2013.01); G01N 2800/22 (2013.01); G01N 2800/52 (2013.01);
Abstract

The subject invention concerns methods and materials for assessing a patient's likelihood of responsiveness to an immunosuppressive therapy. The subject invention is contemplated for use with patients having an autoimmune disorder. In an exemplified embodiment, the methods of the invention are used for assessing and/or treating a patient with MDS. In one embodiment, a method of the invention comprises analyzing T cells of a patient for dysregulation of CD4and/or CD8T cell subsets, and determining the patient's likelihood of responsiveness to IST based on the level of dysregulation of the patient's CD4and/or CD8T cell subsets. In one embodiment, an increased likelihood of patient responsiveness to IST is associated with an increased percentage of CD4and/or CD8effector memory T cells and/or terminal effector memory T cells for a patient. The subject invention also concerns methods for treating a patient with an autoimmune disorder, such as MDS. In one embodiment, a method of the invention comprises determining if a patient is likely to respond to IST, wherein said determination is made using a method of the present invention for assessing likelihood of responsiveness to IST; and if the patient is determined to be one likely to respond to IST, administering an effective regimen of IST to the patient.

Find Patent Forward Citations

Burnette, Pearlie. (2015). Biomarkers for predicting response to immunosuppressive therapy (U.S. Patent No. 9176122). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9176122

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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