The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9175311 B1

PDF
Full Text
Expired
Date of Patent:
Nov. 03, 2015

Filed:

May. 25, 2012
Applicants:

Tim Townes, Birmingham, AL (US);

Kevin M. Pawlik, Birmingham, AL (US);

Inventors:

Tim Townes, Birmingham, AL (US);

Kevin M. Pawlik, Birmingham, AL (US);

Assignee:

The UAB Research Foundation, Birmingham, AL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/867 (2006.01); C12N 15/861 (2006.01); C12N 15/87 (2006.01); C12N 15/79 (2006.01); C12N 15/86 (2006.01); C12N 5/074 (2010.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C12N 5/0696 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/604 (2013.01); C12N 2510/00 (2013.01); C12N 2740/15043 (2013.01); C12N 2800/30 (2013.01);
Abstract

Methods of producing induced pluripotent stem (iPS) cells are provided. For example, a method of producing an iPS cell from a differentiated cell, which includes transforming the differentiated cell with a first vector comprising a nucleic acid sequence comprising a nucleic acid sequence encoding an Oct4, a nucleic acid sequence encoding a Sox2, and a nucleic acid sequence encoding a Klf4. Each of the nucleic acid sequences are separated from each other by a first and second viral 2A sequence. The method described can further comprise culturing the transformed cell under conditions that allow for the production of an iPS cell and isolating the cultured iPS cell.


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Townes, Tim. (2015). Polycistronic vector for human induced pluripotent stem cell production (U.S. Patent No. 9175311). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9175311

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