The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2015
Filed:
Dec. 08, 2010
Applicant:
Bernhard K. Mueller, Neustadt, DE;
Inventor:
Bernhard K. Mueller, Neustadt, DE;
Assignee:
AbbVie Deutschland GmbH & Co. KG, Wiesbaden, DE;
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); C07K 16/00 (2006.01); A61K 39/395 (2006.01); A61K 39/00 (2006.01); C12P 21/08 (2006.01); A61K 49/00 (2006.01); A61K 49/16 (2006.01); C07K 16/22 (2006.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); A61K 2039/505 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01);
Abstract
The present application describes RGM A binding proteins, particularly monoclonal antibodies, and in particular CDR grafted, humanized versions thereof, which have the ability to bind to RGM A and prevent binding of RGM proteins to RGM A receptor and other RGM A binding proteins, and therefore neutralize the function of RGM A, for use in the treatment of retinal nerve fiber layer (RNFL) degeneration as well as methods of therapeutically or prophylactically treating a mammal against RNFL degeneration.