The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2015
Filed:
May. 17, 2010
Terrence R. Burke, Jr., Bethesda, MD (US);
Fa Liu, Indianapolis, IN (US);
Kyung S. Lee, Gaithersburg, MD (US);
Jung-eun Park, Bethesda, MD (US);
Terrence R. Burke, Jr., Bethesda, MD (US);
Fa Liu, Indianapolis, IN (US);
Kyung S. Lee, Gaithersburg, MD (US);
Jung-Eun Park, Bethesda, MD (US);
Abstract
Found in various eukaryotic organisms, polo-like kinases (collectively, Plks) are a conserved subfamily of Ser/Thr protein kinases that play critical roles in cell proliferation. Provided herein are compounds that specifically inhibit the activity of Plks, specifically Plk1. Further provided herein are methods for use of the compounds for the treatment of hyperproliferative disorders, particularly cancer. Also provided are uses of the compounds for the preparation of a medicament.