The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2015
Filed:
Mar. 12, 2013
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Frank Chen, Plainsboro, NJ (US);
Carmela Molinaro, Colonia, NJ (US);
W. Peter Wuelfing, Harleysville, PA (US);
Nobuyoshi Yasuda, Mountainside, NJ (US);
Jianguo Yin, Plainsboro, NJ (US);
Yong-Li Zhong, Edison, NJ (US);
Joseph Lynch, Plainsboro, NJ (US);
Teresa Andreani, Matawan, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The disclosure encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, having less steps and improved yields as compared to previous synthetic methods for making these compounds, which are CGRP receptor antagonists, useful for the treatment of migraine. Conditions for an amide bond formation between an acid and amine include for example reacting the compounds of Formulae B (after salt break) and C with an amide coupling reagent and optionally an additive and an acid and/or a base in a non-reactive solvent.