IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9174963 B1

PDFFull Text
Date of Patent:
Nov. 03, 2015

Filed:

Sep. 04, 2014

Triazine compounds as pi3 kinase and mtor inhibitors

Applicant:

Wyeth Llc, New York, NY (US);

Inventors:

Aranapakam Mudumbai Venkatesan, Rego Park, NY (US);

Zecheng Chen, New City, NY (US);

Christoph Martin Dehnhardt, New York, NY (US);

Osvaldo Dos Santos, Astoria, NY (US);

Efren Guillermo Delos Santos, Nanuet, NY (US);

Arie Zask, New York, NY (US);

Jeroen Cunera Verheijen, Highland Mills, NY (US);

Joshua Aaron Kaplan, Nyack, NY (US);

David James Richard, Warwick, NY (US);

Semiramis Aryl-Kaloustian, Tarrytown, NY (US);

Tarek Suhayl Mansour, New City, NY (US);

Ariamala Gopalsamy, Mahwah, NJ (US);

Kevin Joseph Curran, Congers, NY (US);

Mengxiao Shi, Eastchester, NY (US);

Assignee:

Pfizer Inc., New York, NY (US);

Attorney:

David Rubin

Primary Examiner:

Rebecca Anderson

Int. Cl.
CPC ...
A61K 31/5377 (2006.01); C07D 413/14 (2006.01); C07D 401/12 (2006.01); C07D 251/18 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 413/04 (2006.01); C07D 453/02 (2006.01); C07D 491/113 (2006.01); C07D 498/08 (2006.01); A61K 45/06 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 407/14 (2006.01); C07D 409/12 (2006.01); C07D 451/06 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 251/18 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 407/14 (2013.01); C07D 409/12 (2013.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01); C07D 451/06 (2013.01); C07D 453/02 (2013.01); C07D 491/113 (2013.01); C07D 498/08 (2013.01);
Abstract

Compounds of formula I and R, R, and Rare defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.

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