The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2015
Filed:
Oct. 26, 2006
Lynne Canne Bannen, Pacifica, CA (US);
Diva Sze-ming Chan, San Francisco, CA (US);
Jeff Chen, San Francisco, CA (US);
Lisa Esther Dalrymple, San Francisco, CA (US);
Timothy Patrick Forsyth, Hayward, CA (US);
Tai Phat Huynh, Oakland, CA (US);
Vasu Jammalamadaka, Pleasanton, CA (US);
Richard George Khoury, Redwood City, CA (US);
James William Leahy, San Leandro, CA (US);
Morrison B. Mac, San Francisco, CA (US);
Grace Mann, Brisbane, CA (US);
Larry W. Mann, Redwood City, CA (US);
John M. Nuss, Danville, CA (US);
Jason Jevious Parks, Sacramento, CA (US);
Craig Stacy Takeuchi, Burlingame, CA (US);
Yong Wang, Foster City, CA (US);
Wie Xu, Danville, CA (US);
Lynne Canne Bannen, Pacifica, CA (US);
Diva Sze-Ming Chan, San Francisco, CA (US);
Jeff Chen, San Francisco, CA (US);
Lisa Esther Dalrymple, San Francisco, CA (US);
Timothy Patrick Forsyth, Hayward, CA (US);
Tai Phat Huynh, Oakland, CA (US);
Vasu Jammalamadaka, Pleasanton, CA (US);
Richard George Khoury, Redwood City, CA (US);
James William Leahy, San Leandro, CA (US);
Morrison B. Mac, San Francisco, CA (US);
Grace Mann, Brisbane, CA (US);
Larry W. Mann, Redwood City, CA (US);
John M. Nuss, Danville, CA (US);
Jason Jevious Parks, Sacramento, CA (US);
Craig Stacy Takeuchi, Burlingame, CA (US);
Yong Wang, Foster City, CA (US);
Wie Xu, Danville, CA (US);
Exelixus, Inc., South San Francisco, CA (US);
Abstract
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.