The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 03, 2015

Filed:

Oct. 21, 2009
Applicants:

Masazumi Nagai, Lexington, MA (US);

Jianhua Shen, Andover, MA (US);

Inventors:

Masazumi Nagai, Lexington, MA (US);

Jianhua Shen, Andover, MA (US);

Assignee:

Synta Pharmaceuticals Corp., Lexington, MA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/30 (2006.01); A61P 35/00 (2006.01); A61K 31/28 (2006.01); C07C 327/56 (2006.01); C07D 213/83 (2006.01); C07D 231/14 (2006.01); C07D 307/68 (2006.01);
U.S. Cl.
CPC ...
C07C 327/56 (2013.01); C07D 213/83 (2013.01); C07D 231/14 (2013.01); C07D 307/68 (2013.01); C07C 2101/02 (2013.01);
Abstract

The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I), or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. In one embodiment, the compound is represented by Structural Formula (II), or a prodrug, isomer, ester, salt, hydrate, solvate or polymorph thereof. The present invention also provides a pharmaceutical composition comprising the compound of the invention and method of use thereof.


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