The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2015
Filed:
Sep. 13, 2005
Jefferson Foote, Seattle, WA (US);
Carol E. O'hear, Seattle, WA (US);
Jefferson Foote, Seattle, WA (US);
Carol E. O'Hear, Seattle, WA (US);
Arrowsmith Technologies Corporation, Seattle, WA (US);
Abstract
Compositions and methods are provided in embodiments directed to maintaining a desired concentration range of one or more drugs in a subject, and in particular embodiments to maintaining a desired drug concentration in a body compartment in a subject, based on the surprising discovery that antibodies persist in solution in body compartments such that antibody-antigen equilibrium principles can counteract drug clearance mechanisms. One or more antibodies are selected that have a dissociation constant Kthat is similar to the desired drug concentration, wherein Kis independent of the affinity of the drug for a specific drug target (receptor) in the subject.