The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2015
Filed:
Dec. 14, 2010
Tomas Etrych, Klinec, CZ;
Petr Chytil, Kladno, CZ;
Jiri Strohalm, Prague, CZ;
Karel Ulbrich, Prague, CZ;
Blanka Rihova, Prague, CZ;
Tomas Etrych, Klinec, CZ;
Petr Chytil, Kladno, CZ;
Jiri Strohalm, Prague, CZ;
Karel Ulbrich, Prague, CZ;
Blanka Rihova, Prague, CZ;
USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., Prague, CZ;
MIKROBIOLOGICKY USTAV AV CR, V.V.I., Prague, CZ;
Abstract
The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.