The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 03, 2015

Filed:

Sep. 20, 2013
Applicants:

Cocrystal Pharma, Inc., Tucker, GA (US);

Emory University, Atlanta, GA (US);

Inventors:

Jong Hyun Cho, Snellville, GA (US);

Steven J. Coats, McDonough, GA (US);

Raymond F. Schinazi, Miami, FL (US);

Hongwang Zhang, Tucker, GA (US);

Longhu Zhou, Atlanta, GA (US);

Assignee:

Cocrystal Pharma, Inc., Tucker, GA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); A61K 31/7076 (2006.01); A61K 31/7064 (2006.01); A61K 31/7042 (2006.01); A61K 31/706 (2006.01); A61K 31/708 (2006.01); A61K 31/7068 (2006.01); A61K 31/7052 (2006.01); A61K 31/7028 (2006.01); A61K 45/06 (2006.01); C07H 19/173 (2006.01); C07H 19/20 (2006.01); A61K 31/675 (2006.01); C07D 473/16 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7076 (2013.01); A61K 31/675 (2013.01); A61K 31/706 (2013.01); A61K 31/708 (2013.01); A61K 31/7028 (2013.01); A61K 31/7042 (2013.01); A61K 31/7052 (2013.01); A61K 31/7064 (2013.01); A61K 31/7068 (2013.01); A61K 45/06 (2013.01); C07D 473/16 (2013.01); C07H 19/173 (2013.01); C07H 19/20 (2013.01);
Abstract

The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV in human patients or other animal hosts. The compounds are certain 6-substituted purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV.


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