The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2015
Filed:
Nov. 27, 2007
Katsuyuki Murase, Cupertino, CA (US);
Jinping Wan, Sunnyvale, CA (US);
John Stankus, Campbell, CA (US);
Dariush Davalian, San Jose, CA (US);
Florian Ludwig, Mountain View, CA (US);
Katsuyuki Murase, Cupertino, CA (US);
Jinping Wan, Sunnyvale, CA (US);
John Stankus, Campbell, CA (US);
Dariush Davalian, San Jose, CA (US);
Florian Ludwig, Mountain View, CA (US);
Abbott Cardiovascular Systems Inc., Santa Clara, CA (US);
Abstract
A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.