The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2015
Filed:
Dec. 01, 2011
Applicants:
Yanwei Jia, Waltham, MA (US);
J. Aquiles Sanchez, Framingham, MA (US);
John E. Rice, Quincy, MA (US);
Lawrence J. Wangh, Auburndale, MA (US);
Inventors:
Yanwei Jia, Waltham, MA (US);
J. Aquiles Sanchez, Framingham, MA (US);
John E. Rice, Quincy, MA (US);
Lawrence J. Wangh, Auburndale, MA (US);
Assignee:
Brandeis University, Waltham, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6858 (2013.01); C12Q 1/6858 (2013.01); C12Q 2525/186 (2013.01); C12Q 2525/301 (2013.01); C12Q 2527/107 (2013.01); C12Q 2537/143 (2013.01);
Abstract
This disclosure relates to amplification and detection of a rare variant or variants of a DNA sequence in an abundant variant of the sequence, such as detection of a low-level somatic mutations and minority alleles in an excess of normal nucleic acid target sequences.