The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2015
Filed:
Jan. 05, 2009
Virginia W. Cornish, New York, NY (US);
Pamela P. Perlata-yahya, Oakland, CA (US);
Jonathan Eiseman Bronson, New York, NY (US);
Virginia W. Cornish, New York, NY (US);
Pamela P. Perlata-Yahya, Oakland, CA (US);
Jonathan Eiseman Bronson, New York, NY (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
Abstract
The present invention relates to systems which harness the molecular biology of a living cell to direct evolution of biological entities of interest. According to the invention, a host cell is engineered to facilitate mutation of a nucleic acid target corresponding to that entity and select for desirable mutants. As applied to populations of host cells, the invention provides a means to generate and contemporaneously select mutants of interest, allowing for the production of extremely diverse libraries enriched in the most 'fit' mutants.