The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2015
Filed:
Aug. 30, 2013
Nicolas Pierre Yves Carboulec, Saint Goueno, FR;
Gildas Merian, Bourg la reine, FR;
Rene Labatut, Saint-Genis Laval, FR;
Lionel Gerentes, Lyons, FR;
Nicolas Pierre Yves Carboulec, Saint Goueno, FR;
Gildas Merian, Bourg la reine, FR;
Rene Labatut, Saint-Genis Laval, FR;
Lionel Gerentes, Lyons, FR;
MERIAL, INC., Duluth, GA (US);
Top Industrie S.A.S., , FR;
Abstract
The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.