The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2015
Filed:
Sep. 26, 2012
Shenzhen Haibin Pharmaceutical Co., Ltd., Shenzhen, Guangdong, CN;
Lisong Long, Shenzhen, CN;
Zhaoqiang Lu, Shenzhen, CN;
Cheng Ding, Shenzhen, CN;
Guangcheng Li, Shenzhen, CN;
Zhili Lv, Shenzhen, CN;
Congquan Wu, Shenzhen, CN;
Yanjun Zhang, Shenzhen, CN;
Peng Ren, Shenzhen, CN;
Shenzhen Haibin Pharmaceutical Co., Ltd., Guangdong, CN;
Abstract
The present invention provides a doripenem intermediate compound shown by formula (XIV), wherein PNB is p-nitrobenzyl, and HX is an acid; and when HX is a monobasic acid, n=1; and when HX is a polybasic acid, n=2. The present invention also provides a process for preparing the doripenem intermediate compound (XIV). In addition, the present invention provides a process for preparing doripenem (I) from the doripenem intermediate compound (XIV) in a simple manner, with a high yield and low production costs. The new mono-protected doripenem intermediate compound provided in the present invention contains only one protecting group, reducing the difficulty and complexity in the subsequent de-protection step by catalytic hydrogenation, increasing the yield of the catalytic hydrogenation reaction, and thus reducing the production cost of the final product. The process is easy to operate and suitable for industrialized production.