The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2015
Filed:
Jul. 02, 2014
Applicant:
Southwest Research Institute, San Antonio, TX (US);
Inventors:
Stanton F. McHardy, San Antonio, TX (US);
Richard M. Corbett, Dresher, PA (US);
Donald M. Maxwell, Baltimore, MD (US);
Michael W. Tidwell, Lakehills, TX (US);
Bismarck Campos, San Antonio, TX (US);
Christopher J. Bemben, San Antonio, TX (US);
Assignee:
SOUTHWEST RESEARCH INSTITUTE, San Antonio, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/473 (2006.01); C07D 251/38 (2006.01); C07D 219/12 (2006.01); C07D 401/12 (2006.01); C07D 211/26 (2006.01); C07D 211/58 (2006.01); C07D 213/64 (2006.01); A61K 31/15 (2006.01); A61K 31/4453 (2006.01); A61K 31/513 (2006.01); A61K 31/16 (2006.01); A61K 31/44 (2006.01); A61K 31/445 (2006.01); A61K 31/4468 (2006.01); A61K 31/4545 (2006.01); A61K 31/506 (2006.01); A61K 45/06 (2006.01); C07D 211/34 (2006.01);
U.S. Cl.
CPC ...
C07D 251/38 (2013.01); A61K 31/15 (2013.01); A61K 31/16 (2013.01); A61K 31/44 (2013.01); A61K 31/445 (2013.01); A61K 31/4453 (2013.01); A61K 31/4468 (2013.01); A61K 31/4545 (2013.01); A61K 31/473 (2013.01); A61K 31/506 (2013.01); A61K 31/513 (2013.01); A61K 45/06 (2013.01); C07D 211/26 (2013.01); C07D 211/34 (2013.01); C07D 211/58 (2013.01); C07D 213/64 (2013.01); C07D 219/12 (2013.01); C07D 401/12 (2013.01);
Abstract
The present invention relates to non-charged oxime compounds which are acetyl cholinesterase (AChE) reactivators of inhibited AChE and which protect against organophosphate poisoning both peripherally and in the central nervous system. Also disclosed are pharmaceutical compositions and methods for preparing the reactivator compounds and associated intermediates.