The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2015
Filed:
Jun. 06, 2008
Marc Chevrier, Collegeville, PA (US);
William W. Freimuth, Gaithersburg, MD (US);
Zhenshao Zhong, Potomac, MD (US);
Daniel Odenheimer, Potomac, MD (US);
Marc Chevrier, Collegeville, PA (US);
William W. Freimuth, Gaithersburg, MD (US);
Zhenshao Zhong, Potomac, MD (US);
Daniel Odenheimer, Potomac, MD (US);
Human Genome Sciences, Inc., Rockville, MD (US);
Abstract
The present invention relates to methods and compositions for use in treatment of patients with autoantibody positive disease. In a specific embodiment, the present invention relates to a method of treating a patient that has an ANA titer of 1:80 or greater and/or greater than or equal to 30 IU/ml of anti-dsDNA antibodies in his/her blood plasma or serum comprising administering a therapeutically effective amount of an immunomodulatory agent, such as an antagonist of Neutrokine-alpha. Additionally provided is a method of reducing the frequency and/or quantity of corticosteroid administration to patients. In preferred embodiments, the patient has systemic lupus erythematosus. Methods for determining if a lupus patient is responding to medical treatment are also provided.