The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2015
Filed:
Jun. 11, 2013
Applicant:
The Cleveland Clinic Foundation, Cleveland, OH (US);
Inventors:
Stanley L. Hazen, Pepper Pike, OH (US);
Bruce Levison, Twinsburg, OH (US);
Zeneng Wang, Shaker Heights, OH (US);
Assignee:
THE CLEVELAND CLINIC FOUNDATION, Cleveland, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/045 (2006.01); A61K 31/66 (2006.01); A61K 31/205 (2006.01); A61K 31/695 (2006.01); A61K 45/06 (2006.01); A61K 31/22 (2006.01); A23L 1/30 (2006.01); A23L 2/52 (2006.01); A61K 31/133 (2006.01); A61K 31/663 (2006.01);
U.S. Cl.
CPC ...
A61K 31/045 (2013.01); A23L 1/30 (2013.01); A23L 2/52 (2013.01); A61K 31/133 (2013.01); A61K 31/205 (2013.01); A61K 31/22 (2013.01); A61K 31/66 (2013.01); A61K 31/663 (2013.01); A61K 31/695 (2013.01); A61K 45/06 (2013.01);
Abstract
Provided herein are compositions for the treatment and/or prevention of cardiovascular disease (CVD), and methods of application and use thereof. In particular, the present invention provides treatment and/or prevention of cardiovascular disease with compounds that inhibit the production of TMA in the gut, such as 3,3-dimethyl-1-butanol (DMB) or other compounds represented by Formula I or as shown in FIGS.-