The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2015
Filed:
Jul. 13, 2010
Gregory L. Verdine, Boston, MA (US);
Tom N. Grossmann, Berlin, DE;
Raymond E. Moellering, La Jolla, CA (US);
Tsung-han Johannes Yeh, Jamaica Plain, MA (US);
Yue Rebecca Yue Liang, Cambridge, MA (US);
Youbean Oak, Cambridge, MA (US);
Gregory L. Verdine, Boston, MA (US);
Tom N. Grossmann, Berlin, DE;
Raymond E. Moellering, La Jolla, CA (US);
Tsung-Han Johannes Yeh, Jamaica Plain, MA (US);
Yue Rebecca Yue Liang, Cambridge, MA (US);
Youbean Oak, Cambridge, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
The invention relates to bifunctional stapled or stitched peptides comprising a targeting domain, a linker moiety, and an effector domain, that can be used to tether, or to bring into close proximity, at least two cellular entities (e.g., proteins). Certain aspects relate to bifunctional stapled or stitched peptides that bind to an effector biomolecule through the effector domain and bind to a target biomolecule through the targeting domain. Polypeptides and/or polypeptide complexes that are tethered by the bifunctional stapled or stitched peptides of the invention, where the effector polypeptide bound to the effector domain of the bifunctional stapled or stitched peptide modifies or alters the target polypeptide bound to the targeting domain of the bifunctional peptide. Uses of the inventive bifunctional stapled or stitched peptides including methods for treatment of disease (e.g., cancer, inflammatory diseases) are also provided.