The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 20, 2015

Filed:

May. 18, 2012
Applicants:

Peter G. Schultz, La Jolla, CA (US);

Lei Wang, San Diego, CA (US);

John Christopher Anderson, Berkeley, CA (US);

Jason W. Chin, Cambridge, GB;

David R. Liu, Lexington, MA (US);

Thomas J. Magliery, Columbus, OH (US);

Eric L. Meggers, Marburg, DE;

Ryan Aaron Mehl, San Diego, CA (US);

Miro Pastrnak, Atlanta, GA (US);

Stephen William Santoro, Cambridge, MA (US);

Zhiwen Zhang, San Diego, CA (US);

Inventors:

Peter G. Schultz, La Jolla, CA (US);

Lei Wang, San Diego, CA (US);

John Christopher Anderson, Berkeley, CA (US);

Jason W. Chin, Cambridge, GB;

David R. Liu, Lexington, MA (US);

Thomas J. Magliery, Columbus, OH (US);

Eric L. Meggers, Marburg, DE;

Ryan Aaron Mehl, San Diego, CA (US);

Miro Pastrnak, Atlanta, GA (US);

Stephen William Santoro, Cambridge, MA (US);

Zhiwen Zhang, San Diego, CA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/02 (2006.01); C12N 15/67 (2006.01); C07K 14/00 (2006.01); C12P 21/00 (2006.01); C07K 14/505 (2006.01); C12N 9/00 (2006.01); C12P 13/00 (2006.01); C12P 13/04 (2006.01); C12P 13/22 (2006.01); C12P 19/26 (2006.01);
U.S. Cl.
CPC ...
C12P 21/00 (2013.01); C07K 14/00 (2013.01); C07K 14/505 (2013.01); C12N 9/93 (2013.01); C12N 15/67 (2013.01); C12P 13/00 (2013.01); C12P 13/005 (2013.01); C12P 13/04 (2013.01); C12P 13/22 (2013.01); C12P 19/26 (2013.01); C12P 21/02 (2013.01);
Abstract

This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.


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