The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2015
Filed:
Dec. 12, 2012
Pfizer Inc., New York, NY (US);
Covx Technologies Ireland Limited, Ringaskiddy, Co. Cork, IE;
Gopinath Vedachalam Annathur, Bangalore, IN;
Palani Balu, Cupertino, CA (US);
Rory Francis Finn, Manchester, MO (US);
Jie Huang, San Diego, CA (US);
Olivier Alexandre Laurent, San Diego, CA (US);
Nancy Jane Levin, Encinitas, CA (US);
Nicholas Gary Luksha, North Andover, MA (US);
Joseph Patrick Martin, Jr., Wildwood, MO (US);
Haim Moskowitz, San Diego, CA (US);
Moorthy Sitharamaiah Suriyanarayana Palanki, Encinitas, CA (US);
Mark John Pozzo, Chesterfield, MO (US);
Gregory Allan Waszak, O'Fallon, MO (US);
Jin Xie, Ballwin, MO (US);
COVX TECHNOLOGIES IRELAND LIMITED, Ringaskiddy, Co. Cork, IE;
Abstract
The present invention provides a composition of the formula: [FGF21-1Linker]-[Ab]-[2-Linker-Ex4]; wherein FGF21 is an FGF21 homologue; and Ex4 is an Exendin4 homologue; and Ab is an aldolase catalytic antibody or antigen binding portion thereof; and the 1linker is covalently attached to the side chain of a protein-linking residue in FGF21 and to a combining site of the antibody, and the 2linker is covalently attached to the side chain of a peptide-linking residue in Ex4 and to a combining site of the antibody, and wherein the first and second linker are the same or different. Various uses of the compounds are provided, including methods to prevent or treat diabetes or diabetes-related conditions.