The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 20, 2015

Filed:

Oct. 31, 2013
Applicants:

Jijie Gu, Shrewsbury, MA (US);

Dominic J. Ambrosi, Worcester, MA (US);

Susan E. Lappe, Riverwoods, IL (US);

Yingchun LI, Buffalo Grove, IL (US);

Jonathan A. Hickson, Lake Villa, IL (US);

Deanna L. Haasch, Grayslake, IL (US);

Supriya Gupta, Sunnyvale, CA (US);

Ravi Chari, Worcester, MA (US);

Camellia Zamiri, Fremont, CA (US);

Louie Naumovski, Los Altos, CA (US);

Xianhua Cao, Hawthorn Woods, IL (US);

Inventors:

Jijie Gu, Shrewsbury, MA (US);

Dominic J. Ambrosi, Worcester, MA (US);

Susan E. Lappe, Riverwoods, IL (US);

Yingchun Li, Buffalo Grove, IL (US);

Jonathan A. Hickson, Lake Villa, IL (US);

Deanna L. Haasch, Grayslake, IL (US);

Supriya Gupta, Sunnyvale, CA (US);

Ravi Chari, Worcester, MA (US);

Camellia Zamiri, Fremont, CA (US);

Louie Naumovski, Los Altos, CA (US);

Xianhua Cao, Hawthorn Woods, IL (US);

Assignee:

AbbVie Inc., North Chicago, IL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 39/40 (2006.01); C07K 16/46 (2006.01); A61K 45/06 (2006.01); C07K 16/22 (2006.01); A61K 31/513 (2006.01); A61K 31/7068 (2006.01); A61K 31/337 (2006.01); A61K 31/4745 (2006.01); A61K 31/495 (2006.01); A61K 31/525 (2006.01); C07K 16/28 (2006.01); C07K 16/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/468 (2013.01); A61K 31/337 (2013.01); A61K 31/4745 (2013.01); A61K 31/495 (2013.01); A61K 31/513 (2013.01); A61K 31/525 (2013.01); A61K 31/7068 (2013.01); A61K 39/395 (2013.01); A61K 39/3955 (2013.01); A61K 39/39591 (2013.01); A61K 45/06 (2013.01); C07K 16/22 (2013.01); C07K 16/28 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract

Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases characterized by aberrant DLL4 and/or VEGF expression or activity.


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