The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2015
Filed:
Aug. 18, 2010
Applicants:
Xuebin Qin, Westwood, MA (US);
Weiguo HU, Quincy, MA (US);
Inventors:
Xuebin Qin, Westwood, MA (US);
Weiguo Hu, Quincy, MA (US);
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C12P 21/08 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2896 (2013.01); C07K 16/005 (2013.01); A61K 2039/505 (2013.01); C07K 16/28 (2013.01); C07K 2317/21 (2013.01); C07K 2317/515 (2013.01); C07K 2317/55 (2013.01); C07K 2317/73 (2013.01);
Abstract
The invention features proteins including an antibody, or functional derivatives thereof, that bind hCD59 and have the activity of domain 4 of theintermedins intermedilysin (ILY) protein. In order to prevent the independent induction of CDC and ADCC, the antibodies of the invention can bind the same hCD59 epitope as ILYd4 and/or contain modifications that disrupt the interaction between the antibody and complement.