The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2015
Filed:
Jul. 12, 2012
Junzhi Luo, Shanghai, CN;
Yongqiang Sun, Jiangsu, CN;
Xun Luo, Shanghai, CN;
Yimin Yan, Jiangsu, CN;
Zhaojun Wang, Shanghai, CN;
Mingxia Qian, Jiangsu, CN;
Yongrui Tu, Jiangsu, CN;
Junzhi Luo, Shanghai, CN;
Yongqiang Sun, Jiangsu, CN;
Xun Luo, Shanghai, CN;
Yimin Yan, Jiangsu, CN;
Zhaojun Wang, Shanghai, CN;
Mingxia Qian, Jiangsu, CN;
Yongrui Tu, Jiangsu, CN;
Utopharm (Shanghai) Co., Ltd, Shanghai, CN;
Changzhou No. 4 Pharmaceutical Factory Co., Ltd, Changzhou, Jiangsu, CN;
Abstract
A method as well as new intermediates for preparing Ulipristal acetate (a compound I) and a method for preparing the new intermediates are provided. The intermediate in a constitutional formula IV is conductive to reacting with methyl lithium or methyl Grignard reagent, a protective group is easy to be removed after a reaction, side reactions are few, a mid-term treatment is simple, the reagents used are cheap, costs are low and a yield is high, if a compound in a constitutional formula V is obtained by the reaction of a compound in a constitutional formula III and the intermediate in the constitutional formula IV, the yield of a two-step reaction is 75%, a purity is above 98%. wherein R is defined in the specification.